| Bioactivity | Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent[1]. | ||||||
| Invitro | MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM[1]. Cell Viability Assay[1] Cell Line: | ||||||
| In Vivo | Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min[1]. Animal Model: | ||||||
| Name | Amylin, amide, human | ||||||
| CAS | 122384-88-7 | ||||||
| Sequence | Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge: Cys2-Cys7) | ||||||
| Shortening | KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 (Disulfide bridge: Cys2-Cys7) | ||||||
| Formula | C165H261N51O55S2 | ||||||
| Molar Mass | 3903.28 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Sisnande T, et al. Monoconjugation of Human Amylin with Methylpolyethyleneglycol. PLoS One. 2015 Oct 8;10(10):e0138803. |
Amylin, amide, human
CAS: 122384-88-7 F: C165H261N51O55S2 W: 3903.28
Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique ro
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