Ampreloxetine hydrochloride_product_DataBase

Bioactivity	Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma[1].
In Vivo	Ampreloxetine hydrochloride (0.3- 60mg /kg；口服；单剂量) 在大鼠模型中，其血浆浓度和剂量水平无关[1]。 Animal Model:
Name	Ampreloxetine hydrochloride
CAS	1227056-87-2
Formula	C18H19ClF3NO
Molar Mass	357.80
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Smith JA, et al. Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18(2):pyu027.

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