| Bioactivity | Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively[1]. |
| Target | MIC: 1 μg/mL (Candida albicans 33/079), 8 μg/mL (C.parapsilosis 937A), 1 μg/mL (Cryptococcus neoformans 451), 2 μg/mL (Aspergillus niger 57A) and 2 μg/mL (A.fumigatus) |
| Invitro | Amphotericin X1 (compound 4) shows interesting antifungal activity combined with a pronounced reduction in haemolytic activity (EH50 of 42 μg/mL) against mammalianerythrocytes in vitro[1]. |
| Name | Amphotericin X1 |
| CAS | 136135-57-4 |
| Formula | C48H75NO17 |
| Molar Mass | 938.11 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Taylor AW, et al. Synthesis and antifungal selectivity of new derivatives of amphotericin B modified at the C-13 position. J Antibiot (Tokyo). 1993 Mar;46(3):486-93. |
Amphotericin X1
CAS: 136135-57-4 F: C48H75NO17 W: 938.11
Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits C
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