| Bioactivity | Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities[1][2]. |
| Invitro | Amorfrutin B (1,5 μM, 6 h) 通过基因甲基化和 miRNA 依赖调控抑制凋亡和自噬过程，保护小鼠脑神经元细胞缺氧/缺血[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Amorfrutin B 相关抗体: |
| In Vivo | Amorfrutin B (100 mg/kg, 添加在食物中，两周) 可改善胰岛素抵抗小鼠胰岛素敏感性、葡萄糖耐量和血脂浓度[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 78916-42-4 |
| Formula | C26H32O4 |
| Molar Mass | 408.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Przepiórska K, et al. Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation. Mol Neurobiol. 2023 Feb;60(2):576-595. [2]. Weidner C, et al. Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties. Diabetologia. 2013 Aug;56(8):1802-12. |