| Bioactivity | Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR)[1]. |
| CAS | 150091-68-2 |
| Formula | C16H19Cl2N3O2 |
| Molar Mass | 356.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Amonafide: a potential role in treating acute myeloid leukemia |
Amonafide dihydrochloride
CAS: 150091-68-2 F: C16H19Cl2N3O2 W: 356.25
Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with a
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