Bioactivity | Aminopterin (Standard) is the analytical standard of Aminopterin. This product is intended for research and analytical applications. Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia. |
CAS | 54-62-6 |
Formula | C₁₉H₂₀N₈O₅ |
Molar Mass | 440.41 |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |