| Bioactivity | Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG10-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Invitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| Name | Amino-PEG10-OH |
| CAS | 129449-09-8 |
| Formula | C20H43NO10 |
| Molar Mass | 457.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. James Bailey, et al. Non peptidic heterobivalent molecules for treating inflammatory diseases. WO2018134731A1. |
Amino-PEG10-OH
CAS: 129449-09-8 F: C20H43NO10 W: 457.56
Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-P
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