| Bioactivity | Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα[1]. |
| Target | intercellular adhesion molecule-1 (ICAM-1) |
| Name | Aloenin aglycone |
| CAS | 59163-53-0 |
| Formula | C13H12O5 |
| Molar Mass | 248.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sun Y N, et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239. |
Aloenin aglycone
CAS: 59163-53-0 F: C13H12O5 W: 248.23
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits
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