| Bioactivity | Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1][2][3][4]. | ||||||||||||
| Invitro | Almorexant (1 μM) promotes tyrosine phosphorylation of SHP2/OX1R complex[1].Almorexant (1 μM) inhibits the cellular growth of AsPC-1 cells[1]. | ||||||||||||
| Name | Almorexant | ||||||||||||
| CAS | 871224-64-5 | ||||||||||||
| Formula | C29H31F3N2O3 | ||||||||||||
| Molar Mass | 512.56 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
Almorexant
CAS: 871224-64-5 F: C29H31F3N2O3 W: 512.56
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.