| Bioactivity | Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1][2][3][4]. |
| Invitro | Almorexant hydrochloride (1 μM) promote tyrosine phosphorylation of SHP2/OX1R complex[1].Almorexant hydrochloride (1 μM) inhibits the cellular growth of AsPC-1 cells[1]. |
| Name | Almorexant hydrochloride |
| CAS | 913358-93-7 |
| Formula | C29H32ClF3N2O3 |
| Molar Mass | 549.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Almorexant hydrochloride
CAS: 913358-93-7 F: C29H32ClF3N2O3 W: 549.02
Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with
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