| Bioactivity | Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943). |
| Sequence | {Hex-5-ynoyl}-Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe-Phe-Ala-Met-NH2 |
| Shortening | {Hex-5-ynoyl}-RDFQSFRKMWPFFAM-NH2 |
| Formula | C101H139N25O20S2 |
| Molar Mass | 2087.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bowen Yang, et al. Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3. Bioorg Med Chem Lett. 2024 Nov 1:112:129945. |