| Bioactivity | Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase. Aldose reductase-IN-7 exhibits potent enzyme inhibitory activity (Ki = 0.186 ± 0.020 μM), showing superiority to Epalrestat (HY-66009), which is currently in clinical use. Aldose reductase-IN-7 is less cytotoxic and possesses potent anticancer activity[1]. |
| Invitro | Aldose reductase-IN-7 (24小时) 在 L929 细胞中显示出较低的细胞毒性 (IC50 = 569.58 ± 0.80 μM)。在 MCF-7 细胞中有显著的抗癌活性 (IC50 = 110.87 ± 0.42 μM)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Aldose reductase-IN-7 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| Formula | C21H20N4O7 |
| Molar Mass | 440.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Güleç Ö, et al. Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies. Bioorg Chem. 2024 Apr;145:107221. |
Aldose reductase-IN-7
CAS: F: C21H20N4O7 W: 440.41
Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase. Aldose reductase-IN-7 exhibits potent enzyme inhibitory ac
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