| Bioactivity | Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of dermatitis and skin itch[1][2]. |
| Invitro | Alclometasone dipropionate (0.01-100 ng/mL; 24 h) suppresses cytokine production of CD3/CD2 stimulation with IC50s of 5.54, 1.76, 2.09, 0.89, 3.26 and 0.76 ng/mL for IL-2, IL-3, IL-4, IL-5, IFN-γ and GM-CSF, respectively in human PBMC[1]. |
| In Vivo | Alclometasone dipropionate (0.1% (20 μL); both sides of the ears; once) shows effects on tuberculin- and egg albumin-induced allergic reaction[2]. Animal Model: |
| Name | Alclometasone dipropionate |
| CAS | 66734-13-2 |
| Formula | C28H37ClO7 |
| Molar Mass | 521.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sakuma S, et al. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. [2]. Sengoku T, et al. Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. Eur J Pharmacol. 1999 Aug 27;379(2-3):183-9. |
Alclometasone dipropionate
CAS: 66734-13-2 F: C28H37ClO7 W: 521.04
Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of
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