Albendazole_product_DataBase

Bioactivity

Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].

Invitro

Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner[1].Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle[1].Albendazole (5 µM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner[2].Albendazole (5 µM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells[2].Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells[3]. Cell Proliferation Assay[1] Cell Line:

Name

Albendazole

CAS

54965-21-8

Formula

C12H15N3O2S

Molar Mass

265.33

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

PeptideDB

Albendazole

CAS: 54965-21-8 F: C12H15N3O2S W: 265.33