| Bioactivity | Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2[1]. |
| Invitro | Albanol B（10 μM，30 μM；24 小时）降低 A549 细胞的细胞活力[1]。Albanol B（30 μM；48 小时）抑制 A549 和 H1975 细胞的 G2/M 期细胞周期并诱导细胞凋亡[1]。Albanol B（1-30 μM；1-9 小时）介导 A549 细胞中 ERK-1/2 和 AKT 的激活[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | Albanol B（50 mg/kg、100 mg/kg；腹腔注射；每天一次，持续 21 天）抑制 Ex-3LL 荷瘤小鼠的肿瘤生长[1]。 Animal Model: |
| Name | Albanol B |
| CAS | 87084-99-9 |
| Formula | C34H22O8 |
| Molar Mass | 558.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Phan TN, et al. Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth. Int J Mol Sci. 2020 Dec 14;21(24):9502. |