PeptideDB

Alamifovir

CAS: 193681-12-8 F: C19H20F6N5O5PS W: 575.42

Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivu
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Bioactivity Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].
Invitro MCC-478 (0-10 μM) 对野生型 HBV 的 EC50 为 0.027 μM,对 M552I 为 2.6 μM,对 M552V 为 3.3 μM,对 L528M/M552V 为 2.0 μM[1]。
Name Alamifovir
CAS 193681-12-8
Formula C19H20F6N5O5PS
Molar Mass 575.42
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Suzane Kioko Ono-Nita, et al. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002 Aug;46(8):2602-5. [2]. Danny K W Soon, et al. Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection. J Hepatol. 2004 Nov;41(5):852-8.