Bioactivity | Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2]. |
Invitro | MCC-478 (0-10 μM) 对野生型 HBV 的 EC50 为 0.027 μM,对 M552I 为 2.6 μM,对 M552V 为 3.3 μM,对 L528M/M552V 为 2.0 μM[1]。 |
Name | Alamifovir |
CAS | 193681-12-8 |
Formula | C19H20F6N5O5PS |
Molar Mass | 575.42 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Suzane Kioko Ono-Nita, et al. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002 Aug;46(8):2602-5. [2]. Danny K W Soon, et al. Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection. J Hepatol. 2004 Nov;41(5):852-8. |