AlF-NOTA-c-d-VAP_product_DataBase

Bioactivity	AlF-NOTA-c-d-VAP is a peptide positron emission tomography (PET) probe that used for targeted tumor imaging of GRP78. AlF-NOTA-c-d-VAP demonstrates high stability in vitro and in vivo[1].
In Vivo	在荷瘤小鼠中进行了微型 PET 成像、药代动力学分析和生物分布研究，以评估探针的性能。AlF-NOTA-c-DVAP 放射性标记只需 25 分钟，收率高达 51%，放射化学纯度为 99%，摩尔活度在 20-50 GBq/μmol 范围内。肿瘤中 AlF-NOTA-c-DVAP 的动态 PET 成像显示快速摄取和持续保留，背景摄取最小。生物分布研究表明，遵循单室可逆代谢模型，可快速血液清除并通过肾脏排泄[1]。在 PET 成像中，静脉注射 60 分钟后 A549 肿瘤（GRP78 高表达）、MDA-MB-231 肿瘤（中表达）和 HepG2 肿瘤（低表达）的 T/M 比分别为 10.48%、6.25% 和 3.15% ID /g[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula	C51H83AlFN17O19S
Molar Mass	1316.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jiawen Huang, et al. Synthesis and Evaluation of [18F]AlF-NOTA-c-DVAP: A Novel PET Probe for Imaging GRP78 in Cancer. Mol Pharm. 2024 Mar 30.

PeptideDB