| Bioactivity | Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 µM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC)[1]. |
| Invitro | Akt/mTOR-IN-1 (10 μM, 72 小时) 在 HepG2、MCF-7 和 MDA-MB-231 细胞中表现出有效的抑制活性[1]。Akt/mTOR-IN-1 (2 μM, 12 小时) 在非小细胞肺癌（NSCLC）A549 细胞中通过 AKT/mTOR 信号通路诱导自噬性细胞死亡和凋亡[1]。Akt/mTOR-IN-1 (0.3125-10 μM, 24 小时) 在非小细胞肺癌（NSCLC）A549 细胞中诱导 G2/M 期细胞周期阻滞和凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Akt/mTOR-IN-1 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Formula | C31H21F3N2O3 |
| Molar Mass | 526.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lv L, et al. Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway. Bioorg Chem. 2024 Jul 15;151:107648. |