| Bioactivity | Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC50 of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities[1]. |
| Invitro | Akt/NF-κB/JNK-IN-1 (Compound 2i) (0-50 μM) significantly reduces the levels of TNF-α, IL-1β, IL-6 and PGE2 and markedly downregulates the expression levels of iNOS and COX-2[1]. |
| Name | Akt/NF-κB/JNK-IN-1 |
| Formula | C22H22N2O6 |
| Molar Mass | 410.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shang H, et al. Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways. Eur J Med Chem. 2022 Aug 5;238:114511. |