| Bioactivity | Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity[1][2]. | ||||||||||||
| Invitro | Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1].Ajmalicine inhibits contractions in a concentration-dependent manner (IC50=72.3 ± 22.5 μM)[2].Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3]. | ||||||||||||
| Name | Ajmalicine | ||||||||||||
| CAS | 483-04-5 | ||||||||||||
| Formula | C21H24N2O3 | ||||||||||||
| Molar Mass | 352.43 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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