| Bioactivity | Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC50 of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation[1]. |
| Target | IC50: 3.32 μM (Aha1/Hsp90 interactions) |
| Invitro | Aha1/Hsp90-IN-1 (Compound 17) (10 μM; 24 h) disrupts the Aha1/Hsp90 complex without direct inhibition of Hsp90 protein folding activity[1]. Western Blot Analysis[1] Cell Line: |
| Name | Aha1/Hsp90-IN-1 |
| CAS | 2768265-58-1 |
| Formula | C22H17F3N4O2 |
| Molar Mass | 426.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Keegan BM, et al. Synthesis and Evaluation of Small Molecule Disruptors of the Aha1/Hsp90 Complex for the Reduction of Tau Aggregation. ACS Med Chem Lett. 2022 Apr 15;13(5):827-832. |
Aha1/Hsp90-IN-1
CAS: 2768265-58-1 F: C22H17F3N4O2 W: 426.39
Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with
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