| Bioactivity | Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Aeruginosin 865 has anti-inflammatory effect[1] |
| Invitro | Aeruginosin 865 (pretreatment with 0.1-100 μg/mL) shows significant inhibition of IL-8 (EC50=3.5 μg/mL) and ICAM-1 (EC50=50.0 μg/mL) in hTNF-α-stimulated HLMVECs in a concentration-dependent manner. Aeruginosin 865 does not affect cell viability, even at much higher concentration in HeLa, HepG2 cells[1]. Aeruginosin 865 (100-200 μM) shows high-dose cytotoxicity in Mouse fibrosarcoma cells and with no cytotoxic effect in NIH/3T3 cells[2]. . |
| Name | Aeruginosin 865 |
| CAS | 1611990-01-2 |
| Formula | C41H64N6O14 |
| Molar Mass | 864.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Aeruginosin 865
CAS: 1611990-01-2 F: C41H64N6O14 W: 864.98
Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type pep
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