Adoprazine hydrochloride

CAS: 222551-05-5 F: C24H25ClFN3O2 W: 441.93

Adoprazine (SLV313) hydrochloride is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adopr

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Bioactivity	Adoprazine (SLV313) hydrochloride is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine hydrochloride is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine has the characteristics of atypical antipsychotics[1].
Invitro	Adoprazine hydrochloride 对人类重组 D2、D3、D4、5-HT2B 和 5-HT1A 受体具有高亲和力，pKi 分别为 8.4、8.4、8.0、7.9 和 9.1[1]。Adoprazine hydrochloride 是一种高效多巴胺 D2 受体拮抗剂和有效的血清素 5-HT1A 受体激动剂，Emax 值（10 μM 5-HT 的 % 效应）为 73，pKB 值为 8.5[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Adoprazine hydrochloride 相关抗体:
In Vivo	Adoprazine (0.1-10 mg/kg；口服；单次) hydrochloride 以剂量和时间依赖性方式降低细胞外 5-HT 并增加伏隔核中的多巴胺水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	222551-05-5
Formula	C24H25ClFN3O2
Molar Mass	441.93
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Andrew C McCreary, et al. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsych [2]. Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70.

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