| Bioactivity | Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide promotes osteogenic and adipocyte differentiation[1][2]. |
| Invitro | Adenosine N1-oxide )(1-40 μM, 24 h) 对 2µg/mL LPS (HY-D1056) 诱导的RAW264.7细胞 TNF-α 和 IL-6 分泌有抑制作用[2]。Adenosine N1-oxide )(20/100 μM, 30 mins 增加腹腔巨噬细胞和 RAW264.7 细胞内 cAMP 的产生，并呈剂量依赖性[2]。Adenosine N1-oxide )(5-10 μM, 30 mins) 增加 2µg/mL LPS (HY-D1056) 刺激的 RAW264.7 细胞中 Akt 和 GSK-3β 磷酸化水平[2]。[2]。Adenosine N1-oxide )(1-40 μM, 24 h) 促进 MC3T3-E1 细胞成骨和成脂分化[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Adenosine N1-oxide 相关抗体: Western Blot Analysis[2] Cell Line: |
| In Vivo | Adenosine N1-oxide (口服，135 mg/kg，三次) 可降低 LPS (HY-D1056) 诱导的 BALB/c 小鼠内毒素休克的致死率[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 146-92-9 |
| Formula | C10H13N5O5 |
| Molar Mass | 283.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kohno K, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015;12(1):2. Published 2015 Jan 20. [2]. Ohashi E, et al. Adenosine N1-Oxide Exerts Anti-inflammatory Effects through the PI3K/Akt/GSK-3β Signaling Pathway and Promotes Osteogenic and Adipocyte Differentiation. Biol Pharm Bull. 2019;42(6):968-976. |
Adenosine N1-oxide
CAS: 146-92-9 F: C10H13N5O5 W: 283.24
Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide p
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