| Bioactivity | Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin can inhibit lipid peroxidation and maintain mitochondrial function[1][2]. | ||||||||||||
| Target | IC50: 2 μM (HIF-PHD2) | ||||||||||||
| Name | Adaptaquin | ||||||||||||
| CAS | 385786-48-1 | ||||||||||||
| Formula | C21H16ClN3O2 | ||||||||||||
| Molar Mass | 377.82 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Smirnova NA, et, al. Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol. 2010 Apr 23;17(4):380-91. [2]. Neitemeier S, et, al. Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 May 5;7(5):e2214. |
Adaptaquin
CAS: 385786-48-1 F: C21H16ClN3O2 W: 377.82
Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaqui
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.