| Bioactivity | Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1][2][3]. | ||||||||||||
| Invitro | Adapalene (1-200 μM; 24 h) inhibits the viability of ES-2, HOV-7, MCF-7, Hela, SW1990, HT1080, and MM-468 cells, with IC50s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively[2].Adapalene (10-40 μM; 24 h) induces ES-2 cells apoptosis and inhibits proliferation in vitro[2].Adapalene (3-30 μM; 6-24 h) significantly increases the G1-phase population in LoVo or DLD1 cells[3].Adapalene (1-200 μM) inhibits GOT1 activity, with an IC50 of 21.79 μM[2].Adapalene (10-6-10-3 nM) inhibits the expression of plasma membrane-associated enzyme transglutaminase Type I, with an IC50 of 2.5 nM[1]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Adapalene | ||||||||||||
| CAS | 106685-40-9 | ||||||||||||
| Formula | C28H28O3 | ||||||||||||
| Molar Mass | 412.52 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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