PeptideDB

Actagardin

CAS: 59165-34-3 F: C81H124N20O24S4 W: 1890.23

Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings
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This product is for research use only, not for human use. We do not sell to patients.

Bioactivity Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
CAS 59165-34-3
Sequence {Cys}{Ser}{Gly}{Trp}{Val}{Cys}{Cys}{Leu}{Cys}{Ile}{Cys}{Gly}{Cys}{Val}{Ile}{Cys}{Ala}{Cys} (Carba sulfide bridge:Cys1-Cys6,Cys7-Cys12,Cys9-Cys17,Cys14-Cys19)
Shortening CSGWVCCLCICGCVICAC (Carba sulfide bridge:Cys1-Cys6,Cys7-Cys12,Cys9-Cys17,Cys14-Cys19)
Formula C81H124N20O24S4
Molar Mass 1890.23
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Brötz, et al. New insights into the mechanism of action of lantibiotics—diverse biological effects by binding to the same molecular target. J. Antimicrob. Chemother. 46(1), 1-6 (2000).