Bioactivity | Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan. |
CAS | 59165-34-3 |
Sequence | {Cys}{Ser}{Gly}{Trp}{Val}{Cys}{Cys}{Leu}{Cys}{Ile}{Cys}{Gly}{Cys}{Val}{Ile}{Cys}{Ala}{Cys} (Carba sulfide bridge:Cys1-Cys6,Cys7-Cys12,Cys9-Cys17,Cys14-Cys19) |
Shortening | CSGWVCCLCICGCVICAC (Carba sulfide bridge:Cys1-Cys6,Cys7-Cys12,Cys9-Cys17,Cys14-Cys19) |
Formula | C81H124N20O24S4 |
Molar Mass | 1890.23 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Brötz, et al. New insights into the mechanism of action of lantibiotics—diverse biological effects by binding to the same molecular target. J. Antimicrob. Chemother. 46(1), 1-6 (2000). |