AcrB-IN-4_product_DataBase

Bioactivity	Efflux pump-IN-4 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. Efflux pump-IN-4 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-4 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model[1].
Invitro	Efflux pump-IN-4 (compound G11) (8-128 μg/mL) 与至少一种抗生素（ERY、LEV 和 MIN）表现出出色的抗菌协同作用。Efflux pump-IN-4 与 MIN 显示出抗菌协同作用，并在 8 μg/mL 时将 LEV 的 MIC 值降低 4 倍[1]。Efflux pump-IN-4 (50 μM, 100 μM) 在最低浓度 50 μM 下表现出强抑制活性，可抑制尼罗红外排[1]。Efflux pump-IN-4 (4-256 μg/mL) 不引起小鼠红细胞溶血[1]。
In Vivo	Efflux pump-IN-4 (compound G11) (128 μg/mL；72 小时) 对秀丽隐杆线虫没有显著的体内毒性[1]。
Name	AcrB-IN-4
CAS	2890177-95-2
Formula	C29H34N2O4S
Molar Mass	506.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148.

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