| Bioactivity | Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1]. |
| Name | Acetyl-Hirudin (54-65) (sulfated) |
| CAS | 125441-00-1 |
| Sequence | Ac-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-{Try(SO3H)}-Leu-Gln |
| Shortening | Ac-GDFEEIPEE-{Try(SO3H)}-LQ |
| Formula | C68H95N13O29S |
| Molar Mass | 1590.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272(13):8243-9. |
Acetyl-Hirudin (54-65) (sulfated)
CAS: 125441-00-1 F: C68H95N13O29S W: 1590.60
Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-termin
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