| Bioactivity | Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity[1]. | ||||||||||||
| Invitro | Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; 大肠杆菌) 具有抗菌活性，对于 WT、WT+ PMBN、ΔacrAB、ΔacrAB+PMBN、ΔtolC 和 ΔtolC+ PMBN 的 MIC 值分别为 >25、3.13、25、0.39、1.56 和 0.1 μM[1]。 | ||||||||||||
| Name | Acetyl-CoA Carboxylase-IN-1 | ||||||||||||
| CAS | 179343-23-8 | ||||||||||||
| Formula | C13H9Br2N5 | ||||||||||||
| Molar Mass | 395.05 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525. |
Acetyl-CoA Carboxylase-IN-1
CAS: 179343-23-8 F: C13H9Br2N5 W: 395.05
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA
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