| Bioactivity | Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture[1]. | ||||||||||||
| Invitro | 在培养 3 小时后的大鼠未成熟 Leydig 细胞中，Acephate 以剂量依赖性方式抑制基础雄激素输出，抑制从 0.5 μM 开始。Acephate 在 50 μM 时显着抑制黄体生成素和 8-Br-cAMP 刺激的雄激素输出。Acephate 在 50 μM 时显着抑制孕酮介导的雄激素输出[1]。 | ||||||||||||
| In Vivo | 成年雄性小鼠以 0、7、14 和 28 mg/kg/天的 Acephate 喂养 28 天，在 14 和 28 mg/kg/天的剂量下精子活力和数量均下降[1]。 | ||||||||||||
| Name | Acephate | ||||||||||||
| CAS | 30560-19-1 | ||||||||||||
| Formula | C4H10NO3PS | ||||||||||||
| Molar Mass | 183.17 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Yiyan Wang, et al. Acephate interferes with androgen synthesis in rat immature Leydig cells. Chemosphere. 2020 Apr;245:125597. |
Acephate
CAS: 30560-19-1 F: C4H10NO3PS W: 183.17
Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) ac
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