| Bioactivity | Acazicolcept (ALPN-101), an Fc fusion protein, is a dual inducible T cell costimulator (ICOS)/CD28 antagonist. Acazicolcept has anti-inflammatory activities[1]. |
| In Vivo | Azacicolcept (267-400 μg/mouse; i.p.; twice a week; for 6 weeks) 可减少皮肤和肺纤维化并缓解肺动脉高压[1]。 Animal Model: |
| Name | Acazicolcept |
| CAS | 2797026-97-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cindy Orvain, et al. Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models. Arthritis Res Ther. 2022 Jan 5;24(1):13. |