| Bioactivity | Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1][2][3]. |
| Invitro | Ac-YVAD-CHO 抑制小鼠和人 IL-1β 的 IC50 值分别为 2.5 和 0.7 μM[1]。Ac-YVAD-CHO (0.01-100 μM) 可降低经 LPS 处理的血浆和腹膜液中 IL-1β 的升高[1]。Ac-YVAD-CHO (15.6 μM) 减少 NO 诱导的胸腺细胞凋亡[3]。Ac-YVAD-CHO (15.6 μM，12 小时) 抑制 SNAP 处理的胸腺细胞中 NO 诱导的 PARP 裂解[3]。 Western Blot Analysis[3] Cell Line: |
| Name | Ac-YVAD-CHO |
| CAS | 143313-51-3 |
| Shortening | Ac-YVAD-CHO |
| Formula | C23H32N4O8 |
| Molar Mass | 492.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Ac-YVAD-CHO
CAS: 143313-51-3 F: C23H32N4O8 W: 492.52
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor
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