Ac-Pro-Gly-Pro-OH_product_DataBase

Bioactivity	Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].
Name	Ac-Pro-Gly-Pro-OH
CAS	292171-04-1
Sequence	Ac-Pro-Gly-Pro-OH
Shortening	Ac-PGP-OH
Formula	C14H21N3O5
Molar Mass	311.33
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Patel DF, et al The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017. [2]. Kim SD, et al. Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med. 2011 Jul 15;184(2):243-51.

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