| Bioactivity | Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure[1]. |
| Name | Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2 |
| CAS | 819048-44-7 |
| Sequence | Ac-{d-Arg}-Cys-Glu-His-{d-Phe}-Arg-Trp-Cys-NH2 (Disulfide bridge: Cys2-Cys8) |
| Shortening | Ac-{d-Arg}-CEH-{d-Phe}-RWC-NH2 (Disulfide bridge: Cys2-Cys8) |
| Formula | C51H70N18O11S2 |
| Molar Mass | 1175.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66(10):7063-7065. |
Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2
CAS: 819048-44-7 F: C51H70N18O11S2 W: 1175.35
Ac-DArg-c-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c-NH 2 significantly increases heart rate and blood pr
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