| Bioactivity | Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis[1][2]. | ||||||
| Invitro | Abaloparatide TFA (0-100 nM; 40 min) 增强 MC3T3-E1 细胞中的 Gs/cAMP 信号传导和 β-arrestin 募集[1]。Abaloparatide TFA (0-100 nM) 在 U2OS 细胞中以剂量依赖性方式有效诱导 PTHR1 内化，EC50 值为 0.8 nM[1]。 | ||||||
| Name | Abaloparatide TFA | ||||||
| Sequence | Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-{Aib}-Lys-Leu-His-Thr-Ala-NH2 | ||||||
| Shortening | AVSEHQLLHDKGKSIQDLRRRELLEKLL-{Aib}-KLHTA-NH2 | ||||||
| Formula | C176H301N56F3O51 | ||||||
| Molar Mass | 4074.61 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
Abaloparatide TFA
CAS: F: C176H301N56F3O51 W: 4074.61
Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selecti
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