| Bioactivity | AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. | ||||||||||||
| Target | p38 | ||||||||||||
| Invitro | AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50s of 8.4, 8.1, and 9.0[1]. | ||||||||||||
| Name | AZD7624 | ||||||||||||
| CAS | 1095004-78-6 | ||||||||||||
| Formula | C27H30FN5O3 | ||||||||||||
| Molar Mass | 491.56 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Pehrson R, et al. AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure. J Pharmacol Exp Ther. 2018 Jun;365(3):567-572. |