| Bioactivity | AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM. | ||||||||||||
| Target | IC50: ~12 nM (MCHr1) | ||||||||||||
| In Vivo | In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs[1]. | ||||||||||||
| Name | AZD1979 | ||||||||||||
| CAS | 1254035-84-1 | ||||||||||||
| Formula | C25H26N4O5 | ||||||||||||
| Molar Mass | 462.50 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ploj K, et al. Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs. Br J Pharmacol. 2016 Sep;173(18):2739-51. |