| Bioactivity | AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits the ATM-mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis[1]. | ||||||||||||
| Invitro | AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells[1]. | ||||||||||||
| Name | AZD0156 | ||||||||||||
| CAS | 1821428-35-6 | ||||||||||||
| Formula | C26H31N5O3 | ||||||||||||
| Molar Mass | 461.56 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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