| Bioactivity | AZD-3463 (ALK/IGF1R inhibitor) is an orally active ALK/IGF1R inhibitor, with a Ki of 0.75 nM for ALK. AZD3463 induces apoptosis and autophagy in neuroblastoma cells[1][2][3]. | ||||||||||||
| Invitro | AZD-3463 (0-50 µM; 72 h) suppresses the viability and proliferation of both wild type and mutant ALK NB cells[1].AZD-3463 (10 µM; 0-4 h) effectively inhibits ALK-mediated PI3K/AKT/mTOR signaling and induces apoptosis and autophagy in NB cells[1].AZD-3463 (0-100 nM; 4 h) inhibits FLT3-ITD-mediated activation of AKT, ERK1/2 and p38 in a dose-dependent manner in MOLM-13 and MV4-11 cells[2]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | AZD-3463 | ||||||||||||
| CAS | 1356962-20-3 | ||||||||||||
| Formula | C24H25ClN6O | ||||||||||||
| Molar Mass | 448.95 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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AZD-3463
CAS: 1356962-20-3 F: C24H25ClN6O W: 448.95
AZD-3463 (ALK/IGF1R inhibitor) is an orally active ALK/IGF1R inhibitor, with a Ki of 0.75 nM for ALK. AZD3463 induces ap
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