| Bioactivity | AZ5385 is an EGFR-tyrosine kinase inhibitor. AZ5385 is a HRV-2 virus blocker, with EC50 of 0.35 µM. AZ5385 affects the late stage of viral life cycle[1]. |
| Invitro | AZ5385 (72 小时) 对 HeLa 细胞的 CC50 为 9 µM[1]。AZ5385 (添加病毒前孵育 3 小时，然后与病毒在 37°C 共孵育 72 小时) 也抑制 HRV-16 和 RSV A2 株对 HEp-2 细胞的感染，EC50s 分别为 3.6 和 0.4 µM [1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AZ5385 相关抗体: |
| CAS | 848439-89-4 |
| Formula | C22H22ClFN4O4 |
| Molar Mass | 460.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miah M, et al. Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human rhinovirus. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0106423. |