| Bioactivity | AZ11657312 is a P2X7 receptor antagonist with activity to restore stress natriuresis. AZ11657312 significantly increased renal medullary perfusion, only in mice treated with angiotensin II. AZ11657312 improves tissue oxygenation by blocking P2X7R, especially in areas of the kidney that are underoxygenated. Administration of AZ11657312 increased sodium excretion up to sixfold while normalizing blood pressure[1]. |
| CAS | 804561-22-6 |
| Formula | C26H35N3O3 |
| Molar Mass | 437.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Inhibition of the purinergic P2X7 receptor improves renal perfusion in angiotensin-II-infused rats |
AZ11657312
CAS: 804561-22-6 F: C26H35N3O3 W: 437.57
AZ11657312 is a P2X7 receptor antagonist with activity to restore stress natriuresis. AZ11657312 significantly increased
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