| Bioactivity | AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1]. |
| Target | IC50: ~10 nM (P2X7R) |
| Name | AZ10606120 dihydrochloride |
| CAS | 607378-18-7 |
| Formula | C25H36Cl2N4O2 |
| Molar Mass | 495.48 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7(1):725. |
AZ10606120 dihydrochloride
CAS: 607378-18-7 F: C25H36Cl2N4O2 W: 495.48
AZ10606120 dihydrochloride is a selective, high affinity antagonist forP2X7 receptor (P2X7R) at human and rat with an IC
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