| Bioactivity | AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines[1]. |
| Invitro | AZ-TAK1（0.1μM）分别在28%，24% 和 74%的Mino、SP53 和 Jeko 细胞中诱导凋亡[1]。AZ-TAK1 增加了线粒体去极化程度，表现为红色/绿色荧光强度比值降低[1]。 |
| Name | AZ-TAK1 |
| CAS | 1413440-36-4 |
| Formula | C25H28FN7O2 |
| Molar Mass | 477.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Daniela Buglio, et al. Essential role of TAK1 in regulating mantle cell lymphoma survival. Blood. 2012 Jul 12;120(2):347-55. |