| Bioactivity | AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1]. | ||||||||||||
| Invitro | AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM[1].AZ-Dyrk1B-33 shows no effect in sensitization[1]. | ||||||||||||
| Name | AZ-Dyrk1B-33 | ||||||||||||
| CAS | 1679330-37-0 | ||||||||||||
| Formula | C19H16N4 | ||||||||||||
| Molar Mass | 300.36 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44. |