| Bioactivity | AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release[1][2]. |
| Target | PAR2 |
| Name | AY77 |
| CAS | 1835734-92-3 |
| Sequence | {5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2 |
| Shortening | {5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2 |
| Formula | C21H32N4O4 |
| Molar Mass | 404.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Klösel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323. [2]. Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226. |