| Bioactivity | AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1]. |
| Invitro | AUTAC1 (1-100 μM, 24 h) silences endogenous FKBP12 in hela cells[1]. Western Blot Analysis[1] Cell Line: |
| Name | AUTAC2 |
| CAS | 2241669-08-7 |
| Formula | C61H81FN10O14S |
| Molar Mass | 1229.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10. |
AUTAC2
CAS: 2241669-08-7 F: C61H81FN10O14S W: 1229.42
AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and a
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