| Bioactivity | AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2[1]. |
| Invitro | AUTAC1 (1-100 μM, 24 h) silences endogenous MetAP2 in hela cells[1]. Western Blot Analysis[1] Cell Line: |
| Name | AUTAC1 |
| CAS | 2241669-09-8 |
| Formula | C44H63FN8O11S |
| Molar Mass | 931.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10. |
AUTAC1
CAS: 2241669-09-8 F: C44H63FN8O11S W: 931.08
AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to prov
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