| Bioactivity | AURKA against 1 is an inhibitor of AURKA (IC50 less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-proliferation activity against tumor cells. AURKA against 1 induces K162 acetylation, and the kinase activity of AURKA is reversibly restored in HCT116 cells transfected with SIRT3[1]. |
| Invitro | Ac13 (0-10 μM，3 h) 抗肿瘤增殖，在 K562，HL-60，CCRF-CEM 细胞中 GI50 为 588，86，6.6 nM，以剂量依赖的方式抑制 AURKA 的自磷酸化，抑制细胞活性[1]。Ac13 (10 μM，1 h) 诱导的内源性 AURKA 的 K162 乙酰化在表达 SIRT3 的 HCT116 细胞中是可逆的[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AURKA against 1 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C28H32FN9O2 |
| Molar Mass | 545.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guanghui Tang, et al. Small Molecule-Induced Post-Translational Acetylation of Catalytic Lysine of Kinases in Mammalian Cells. J Am Chem Soc. 2024 Aug 28;146(34):23978-23988. |