| Bioactivity | ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1]. |
| Name | ATX inhibitor 15 |
| CAS | 2484811-52-9 |
| Formula | C27H32ClN5O4S |
| Molar Mass | 558.09 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951. |
ATX inhibitor 15
CAS: 2484811-52-9 F: C27H32ClN5O4S W: 558.09
ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.